iS Clinical Super Serum Advance Plus vs. Poly Vitamin Serum: Which is Better in 2025?

 

I’ve been using these two products for a long time, and I think I can confidently say that I know what they’re capable of and how they make me feel. Today, I’m going to share my thoughts and experiences from using them. If you’re looking for a serum that truly works, this blog might be useful for you.

Contents

• Their Key Differences

• Comparing Their Main Features

• Cost and Value

• Hands-On Experience

• Getting Help and Guidance

• Who Should Use These

Super Serum Advance Plus vs. Poly Vitamin Serum at a Glance

Their Key Differences

1. Formulation & Target Concerns

• Super Serum Advance +: Formulated with Vitamin C (L-ascorbic acid), copper tripeptide, and brightening agents like kojic acid and arbutin. It’s meant to handle acne scarring, stretch marks, and uneven skin tone.

• Poly Vitamin Serum: Packs multiple vitamins (A, B, E) plus AHAs (glycolic and lactic acid) for enhanced cell turnover and hydration. It’s great for people with compromised, dehydrated, or dull skin.

2. Texture & Sensation

• Super Serum Advance Plus: Absorbs fast with zero stickiness. I felt a slight tingling sensation, but it subsided quickly, and I could layer other products almost immediately.

• Poly Vitamin Serum: Tingling can be stronger—almost an “itchy” feeling right after application—yet it does leave the skin feeling plump and moisturized, albeit a bit stickier.

3. Use With Other Products

• Super Serum Advance Plus: When combined with heavier creams (like Skinceuticals Triple Lipid), I sometimes developed milia. I learned to wait a bit before layering a thicker moisturizer.

• Poly Vitamin Serum: Despite being stickier, it did not give me any issues with milia. Plus, it kept my skin looking fresh even during long flights and climate changes.

Comparing Their Main Features

Feature 1: Anti-Aging & Scar Reduction

Super Serum Advance Plus: Loaded with copper tripeptide and Vitamin C to support collagen production. I noticed smoother texture around acne scars and less visible hyperpigmentation by week two.

Poly Vitamin Serum: Vitamins A, B, and E, plus AHAs, help promote cell turnover. Great for overall anti-aging, but I found the scar-reducing effects slightly less direct than the Super Serum.

My Take:
If you’re dealing with acne scars or stretch marks, Super Serum might give you faster, more targeted results.

Feature 2: Brightening & Even Skin Tone

Super Serum Advance Plus: Incorporates arbutin and kojic acid, known for brightening. My skin looked more even and radiant fairly quickly.

Poly Vitamin Serum: AHAs gently exfoliate, which also brightens over time. Offers a “plump glow,” but it felt like a slower brightening process compared to the Super Serum.

My Take:
Both serums significantly improved my skin tone, but if you want a noticeable boost in about two weeks, Super Serum might be slightly quicker.

Feature 3: Hydration & Overall Resilience

Super Serum Advance Plus: Contains hyaluronic acid; keeps skin hydrated without leftover residue. Might cause congestion if you’re layering a heavy cream too soon afterward.

Poly Vitamin Serum: The added vitamins and hyaluronic acid give a more intense hydration experience. I especially appreciated it during travel or harsh weather changes—my skin looked revived despite the stress.

My Take:
If dehydration is a big concern or you need a post-travel recovery serum, Poly Vitamin might be your go-to.

Cost and Value

iS Clinical Super Serum Advance Plus: $227 (cheaper when on sale)

Definitely a splurge, but if you need robust antioxidant protection and targeted scar-lightening, it’s worth considering.

iS Clinical Poly Vitamin Serum: $153 (cheaper when on sale)

More budget-friendly while still delivering powerful hydration and vitamins. Perfect if you’re easing into the iS Clinical line without wanting to commit to the higher price of the Super Serum right away.

Hands-On Experience 

iS Clinical Super Serum Advance Plus

• Texture & Absorption: Light, non-sticky, immediate soak-in.

• Sensation: Slight tingle that fades quickly.

• Layering: Leaves skin dry enough to apply moisturizers right away, but I recommend waiting a few minutes if using a heavy cream.

iS Clinical Poly Vitamin Serum

• Texture & Absorption: A bit stickier, especially at first.

• Sensation: Stronger, itchy-tingling effect, but still tolerable.

• Layering: No issues with milia for me, even with heavier lotions or creams.

Over four weeks, each serum visibly improved my skin’s texture, brightness, and overall health. However, Poly Vitamin Serum gave me that extra hydration I needed during travel, while Super Serum Advance Plus tackled my older acne scars more effectively.

Getting Help and Guidance

iS Clinical typically provides usage instructions on their website and product packaging:

• Official Website: Detailed guides, ingredient breakdowns, and recommended usage for specific concerns.

• Authorized Retailers: Many skincare professionals and official retailers offer personalized consultations.

• Community Feedback: Online forums, social media groups, and skincare communities often share real-world tips and experiences.

Who Should Use These

When to Choose iS Clinical Super Serum Advance Plus

• You have acne scars or mild stretch marks that need serious attention.

• You want a powerful Vitamin C formula with additional brightening agents like kojic acid and arbutin.

• You prefer a lightweight, fast-absorbing serum that isn’t sticky.

When to Choose iS Clinical Poly Vitamin Serum

• You need deep hydration and skin revitalization, especially if you have dry or compromised skin.

• You appreciate a multi-vitamin approach for a youthful glow and overall skin health.

• You want a more budget-friendly but still potent serum.

Final Thoughts

I honestly love both the Super Serum Advance Plus and the Poly Vitamin Serum—so much so that I can’t imagine my skincare routine without them. Here’s my quick recap:

• Super Serum Advance Plus: Marvelous for targeting scars, brightening skin tone faster, and delivering a powerful Vitamin C punch without leaving a sticky residue.

• Poly Vitamin Serum: My go-to for intense hydration, especially if my skin is feeling dull or dehydrated. The tingle can be stronger, but the payoff is worth it if you’re after a plump, nourished look.

If you’re on the fence about which one to try first, consider your main skin priority. Acne scars? Go for Super Serum Advance Plus. Extremely dry or dull skin? Poly Vitamin Serum will be your new best friend.

Tips

• My skin is combination and somewhat acne-prone. Results can vary based on your skin type and tolerance.

• Always patch test new serums if you have sensitive or reactive skin.

• Keep an eye on pricing updates—these figures can change or go on sale.

Final Note: Both serums have become staples in my skincare collection. If you’re looking for a brand that does what it promises—brightening, hydrating, and healing—the iS Clinical lineup deserves a top spot on your shelf.